Clinical Decision Support for Child Abuse: Recommendations from a Consensus Conference

• 2023

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• Srinivasan Suresh; Isabel Barata; David Feldstein; Emily Heineman; Daniel Lindberg; Tammy Bimber
PMID: 35817134DOI: https://doi.org/10.1016/j.jpeds.2022.06.039

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The article titled "Genetics and biology of adult human male germ cell tumors" explores the genetic and biological aspects of germ cell tumors (GCTs) in adult males. It discusses the transformation of totipotential germ cells into pluripotential tumor cells, highlighting their histological differentiation and sensitivity to cisplatin-based chemotherapy. The study examines the molecular mechanisms of GCT transformation, differentiation, and chemotherapy resistance, proposing novel genetic models. Key findings include the overexpression of cyclin D2 as an early oncogenic event and the role of p53-dependent apoptotic pathways in chemotherapy sensitivity.

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Tags

Focus Area: Trauma

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Keywords: Child Abuse; Consensus; Decision Support Systems, Clinical

Institutions: Children's Hospital of Pittsburgh; University of Wisconsin - Madison; University of Colorado; Northwell Health; Mary Bridge Children’s Hospital; Riley Children's Health

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