Nirsevimab Effectiveness at Preventing RSV-Related Hospitalization in Infants

• 2025

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• Marie Jabagi; Jérémie Cohen; Marion Bertrand; Martin Chalumeau; Mahmoud Zureik
PMID: 39998305DOI: https://doi.org/10.1056/evidoa2400275

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About

This study looks at how well nirsevimab works to prevent hospital stays for infants with RSV-related lung infections. It uses data from France, comparing infants who got the treatment to those who didn't. The results show that nirsevimab reduces hospitalizations by 65% and is also effective in preventing more severe cases needing intensive care or breathing support. The study involved over 82,000 infants and found consistent benefits across different groups. It concludes that a single dose of nirsevimab offers strong protection against serious RSV infections in babies without any financial backing influencing the research outcomes.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Response

Bundles: Nirsevimab Library

Keywords: Hospitalization; Immunization; Infant, Newborn; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses

Institutions: EPI-PHARE; Paris Cité University

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