Nirsevimab Binding-Site Conservation in Respiratory Syncytial Virus Fusion Glycoprotein Worldwide Between 1956 and 2021: An Analysis of Observational Study Sequencing Data

• 2023

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• Deidre Wilkins; Annefleur Langedijk; Robert Jan Lebbink; Christopher Morehouse; Michael Abram; Bahar Ahani
PMID: 36940703DOI: https://doi.org/10.1016/s1473-3099(23)00062-2

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This article examines nirsevimab, a monoclonal antibody developed to protect infants from the respiratory syncytial virus (RSV) for a whole season. Studies have shown that the nirsevimab binding site is mostly unchanged between 2015 and 2021. Research examined the prevalence of RSV A and B and identified some nirsevimab binding-site substitutions. Despite some new variants, the nirsevimab binding site has remained stable. Overall, escape variants to nirsevimab are rare and have not increased over time.

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Tags

Hazard: Infectious Disease

Audiences: Nurses; Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Collection: Niresivemab Library

Keywords: Binding Sites; Infant; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Genetic Variation; Viral Fusion Proteins; Sequence Analysis, DNA; Antibodies, Monoclonal, Humanized

Institutions: AstraZeneca; University Medical Center Utrecht

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