Improving Palivizumab Administration to High-Risk Infants with Heart Disease via a Communication-Based Quality Improvement Initiative

• 2025

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• David Leone; Alexis Rodriguez; Kirsten Cowenhoven; Matthew O'Connell; Matthew Grossman; Dina Ferdman
PMID: 38300318DOI: https://dx.doi.org/10.1007/s00246-023-03388-3

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This article describes a project to improve the administration of palivizumab, a medication for high-risk infants with heart disease. A team at Yale University worked over two years to increase the rate of doses given. They used better communication and tracking methods to identify eligible infants. The percentage of monthly doses increased from 57.6% to 78.4%. However, the number of infants receiving at least 80% of their doses rose from 42.1% to only 60%, which was not statistically significant. The study shows that proper identification and tracking can help improve treatment rates for these vulnerable infants.


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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Communication; Heart Diseases; Infant; Respiratory Syncytial Viruses; Palivizumab; Quality Improvement

Institutions: Yale University; Yale New Haven Health System

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