An Evaluation of 2015-2019 United States Respiratory Syncytial Virus Hospitalizations as a Framework to Develop Potential Strategies for the Prevention of the Hospital Burden Among Infants

• 2024

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• Robert Suss; Eric Simões
PMID: 39257959DOI: https://dx.doi.org/10.1016/j.eclinm.2024.102790

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This article evaluates RSV hospitalizations in the U.S. from 2015 to 2019 to develop strategies for reducing hospital burdens among infants. It describes two prevention methods: nirsevimab, a monoclonal antibody, and the RSVpreF maternal vaccine. The study uses data from children's hospitals to compare these strategies based on birth timing relative to the RSV season. Findings suggest that both methods can prevent many hospitalizations but vary in effectiveness depending on when infants are born during the season. The study emphasizes tailoring immunization strategies based on regional RSV patterns for better cost-effectiveness and protection outcomes.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antibodies, Monoclonal; Cohort Studies; Epidemiology; Hospitalization; Infant, Newborn; Respiratory Syncytial Virus Infections; United States; Vaccination

Institutions: University of Colorado; University of Colorado Anschutz; Children's Hospital Colorado

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