Respiratory Syncytial Virus Infection: Old Challenges and New Approaches

• 2023

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• Octavio Ramilo; Rosa Rodriguez-Fernandez; Asuncion Mejia
PMID: 36715631DOI: https://dx.doi.org/10.1093/infdis/jiad010

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About

This article discusses respiratory syncytial virus (RSV), a major threat to child health causing acute and long-term morbidity. It explains the structure and function of RSV, its impact globally, and challenges in developing vaccines. Recent developments in RSV prevention include new vaccine platforms and monoclonal antibodies targeting specific RSV proteins. Strategies for different age groups are explored, such as maternal immunization and mAbs for infants. Promising results show significant reductions in severe RSV infections. The article emphasizes the need for further research to optimize prevention strategies and reduce RSV-associated morbidity and mortality across all age groups.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antibodies, Monoclonal; Child Health Services; Immunization, Passive; Infant; Infant, Newborn; Pregnancy; Pregnant Women; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vaccines, Synthetic; Immunization Programs; Respiratory Syncytial Virus, Human; Antibodies, Monoclonal, Humanized

Institutions: St. Jude Children's Research Hospital; Instituto de Investigación Sanitaria Gregorio Marañón (IISGM); Nationwide Children's Hospital

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