Single-Dose Nirsevimab Prevents RSV Infection

• 2021

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• Shabir Madhi; Eric Simões
PMID: 33342497DOI: https://doi.org/10.1016/j.jpeds.2020.10.066

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This article commentary discusses a study on nirsevimab, a single-dose treatment that helps prevent RSV infections in preterm infants. Conducted across 164 sites in 23 countries, the trial showed that nirsevimab reduced RSV-related lung infections and hospitalizations. It was more effective than placebo, with significant reductions in risk and fewer needed treatments to see benefits. The study highlights the lack of licensed vaccines for RSV and suggests nirsevimab as a promising option. However, concerns about viral mutations affecting its effectiveness and issues like cost may limit access for children in low-income areas.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Infant; Infant, Newborn; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Respiratory Tract Infections; Antibodies, Monoclonal, Humanized

Institutions: University of the Witwatersrand; University of Colorado

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