Durability of Neutralizing RSV Antibodies Following Nirsevimab Administration and Elicitation of the Natural Immune Response to RSV Infection in Infants

• 2023

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• Deidre Wilkins; Yuan Yuan; Yue Chang; Anastasia Aksyuk; Beatriz Nuñez; Ulrika Wählby-Hamrén
PMID: 37095249DOI: https://dx.doi.org/10.1038/s41591-023-02316-5

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This article describes a study on nirsevimab, a medicine used to protect infants from RSV, a virus causing lung infections. Nirsevimab is given as an injection and works by blocking the virus from entering cells. The study found that nirsevimab provides strong protection for infants during their first RSV season and allows them to develop their own immune response. It also explains how nirsevimab is administered, its safety profile, and potential side effects like rash or fever. Healthcare professionals are advised on proper storage and handling of the medication.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antibodies, Monoclonal; Immunization, Passive; Infant, Newborn; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Viral Fusion Proteins; Premature Birth

Institutions: AstraZeneca

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