Safety and Efficacy of Nirsevimab in a Universal Prevention Program of Respiratory Syncytial Virus Bronchiolitis in Newborns and Infants in the First Year of Life in the Valle d'Aosta Region, Italy, in the 2023-2024 Epidemic Season

• 2024

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• Alessandra Consolati; Mariapaola Farinelli; Paolo Serravalle; Christine Rollandin; Laura Apprato; Susanna Esposito
PMID: 38793800DOI: https://doi.org/10.3390/vaccines12050549

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This article describes a study on the safety and effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV bronchiolitis in newborns and infants during the 2023-2024 epidemic season in Valle d'Aosta, Italy. The study found that nirsevimab significantly reduced hospitalizations for RSV bronchiolitis compared to previous seasons. It also reports mild side effects like fever and injection site reactions. The research highlights the potential cost savings from fewer hospital admissions and suggests further studies on long-term impacts and cost-effectiveness of using nirsevimab as a universal preventive measure against RSV infections.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Bronchiolitis; Infant; Infant, Newborn; Italy; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Antibodies, Monoclonal, Humanized

Institutions: Local Health Authority Valle d'Aosta; University of Turin; University of Parma

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