Safety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease

• 2023

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• Joseph Domachowske; Yue Chang; Victoria Atanasova; Fernando Cabañas; Kenji Furuno; Kim Nguyen
PMID: 37466917DOI: https://doi.org/10.1093/jpids/piad052

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About

This study looks at the safety of giving a second dose of nirsevimab to children with heart or lung disease before their second RSV season. It describes how nirsevimab, a long-lasting antibody, is similar in safety to palivizumab and effective in preventing severe RSV infections. The research involved 262 children and found no serious side effects or deaths. Most kids reached the desired levels of protection against RSV. The study was done during COVID-19, which affected RSV spread but still showed that nirsevimab is safe for these high-risk children entering their second season.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antibodies, Monoclonal; Antiviral Agents; Heart Defects, Congenital; Infant; Lung Diseases; Pharmacokinetics; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Lung Diseases, Obstructive; Palivizumab

Institutions: State University of New York - Upstate Medical University; AstraZeneca; Dr. Georgi Stranski University Hospital; Quironsalud Madrid University Hospital; Fukuoka Children's Hospital; Hôpital Femme-Mere-Enfant

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