Impact of Nirsevimab Prophylaxis on Paediatric Respiratory Syncytial Virus (RSV)-Related Hospitalisations During the Initial 2023/24 Season in Luxembourg

• 2024

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• Corinna Ernst; Dritan Bejko; Leo Gaasch; Emilie Hannelas; Isaline Kahn; Charlotte Pierron
PMID: 38275017DOI: https://dx.doi.org/10.2807/1560-7917.ES.2024.29.4.2400033

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This study examines the impact of nirsevimab, a new antibody, on reducing RSV-related hospitalizations in Luxembourg during the 2023/24 season. After its introduction, neonatal coverage reached 84%, leading to fewer hospital admissions for infants under six months compared to 2022. The average age of hospitalized children increased, and their hospital stays were shorter. Most severe cases involved non-immunized children. Nirsevimab's effectiveness aligns with clinical trials showing it reduces RSV severity in infants. The study highlights its potential benefits but notes limitations like short observation time and lack of outpatient data monitoring.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Hospitalization; Infant; Infant, Newborn; Luxembourg; Pediatrics; Respiratory Syncytial Virus Infections; Immunization Programs; Respiratory Syncytial Virus, Human; Antibodies, Monoclonal, Humanized

Institutions: European Centre for Disease Prevention and Control (ECDC); European Centre for Disease Prevention and Control (ECDC); Centre Hospitalier de Luxembourg

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