Rapid Review Showed That Real-World Results on How Nirsevimab Prevented Respiratory Syncytial Virus Hospitalisations Were Similar to Randomised Trials

• 2024

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• Ilari Kuitunen; Marjo Renko
PMID: 38780142DOI: https://doi.org/10.1111/apa.17301

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This brief report describes a study on nirsevimab, a treatment to prevent RSV hospitalizations in infants. Real-world results from studies in Luxembourg, Spain, and the USA showed similar effectiveness to earlier trials. In Luxembourg, hospitalizations dropped by 69%. The Spanish study found an 84% effectiveness rate using a Bayesian approach. The American study reported 90% effectiveness with low coverage rates. Despite some limitations like short monitoring periods and small sample sizes, these findings provide useful insights for decision-makers about nirsevimab's potential impact on preventing RSV-related hospitalizations in infants worldwide.

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Tags

Focus Area: Infectious Disease

Audiences: Nurses; Physicians; Public Health Professionals

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antiviral Agents; Hospitalization; Infant; Luxembourg; Respiratory Syncytial Virus Infections; Spain; United States; Antibodies, Monoclonal, Humanized

Institutions: University of Eastern Finland; Kuopio University Hospital

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