Monoclonal Antibody Therapies in Respiratory Syncytial Virus Prophylaxis-An Umbrella Review

• 2024

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• Ilari Kuitunen; Katri Backman; Eveliina Gärdström; Marjo Renko
PMID: 38751021DOI: https://dx.doi.org/10.1002/ppul.27041

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This article reviews the use of monoclonal antibodies to prevent respiratory syncytial virus (RSV) in infants. It describes how RSV causes many hospitalizations and deaths in young children. Monoclonal antibodies like palivizumab and nirsevimab help reduce RSV-related hospital visits, especially in preterm babies. While these treatments are effective against infections, they don't lower death rates from RSV. The review highlights the need for more studies on real-world effectiveness and safety as new prevention methods emerge, including vaccines for pregnant women to protect newborns from RSV during their first months of life.

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Tags

Focus Area: Infectious Disease

Audiences: Nurses; Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antibodies, Monoclonal; Child; Hospitalization; Infant; Infant Mortality; Infant, Newborn; Infant, Premature, Diseases; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Respiratory Tract Infections; Palivizumab; Antibodies, Monoclonal, Humanized

Institutions: University of Eastern Finland; Kuopio University Hospital

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