Nirsevimab Brings Breakthrough in the Prevention of Respiratory Syncytial Virus Infection in Infants - Importance of Design

• 2023

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• Getu Zhaori
PMID: 37324599DOI: https://doi.org/10.1002/ped4.12377

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This editorial reviews the clinical studies on nirsevimab and discusses what roles the design has played in the studies. Nirsevimab is a monoclonal antibody that blocks the virus from entering cells. Clinical trials showed it is safe and effective, reducing RSV-related hospital visits by over 70%. The design of both the drug and clinical trials was crucial for its success. Trials included diverse infant groups to ensure broad safety and effectiveness. Nirsevimab has been approved in Europe and the UK due to these positive results, marking a significant step forward in preventing severe RSV infections in young children.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Clinical Trials as Topic; Infant; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Antibodies, Monoclonal, Humanized

Institutions: Capital Medical University

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