Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel

• 2022

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• Nitai Levy; Jordanna Koppel; Or Kaplan; Hadas Yechiam; Keren Shahar-Nissan; Naama Kuchinski Cohen; Itai Shavit
PMID: 35588048DOI: https://doi.org/10.1001/jama.2022.8025

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This article examines multisystem inflammatory syndrome in children (MIS-C) during three COVID-19 waves in Israel: Alpha, Delta, and Omicron. It describes how the severity of MIS-C decreased over time, with fewer ICU admissions and better cardiac outcomes during the Omicron wave. The study also found that MIS-C incidence was lower during the Omicron wave compared to Alpha and Delta. Possible reasons include changes in the virus variant, prior infections or vaccinations, and improved treatments. Data were collected from 12 hospitals covering most pediatric ICU admissions in Israel over specific periods for each wave.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Response

Keywords: Child Health; Israel; Pandemics; COVID-19

Institutions: Hillel Yaffe Medical Center; Meir Medical Center; Rambam Health Care Campus; Schneider Children's Medical Center; Sheba Medical Center; Soroka Medical Center

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